United appeared to make comforting progress after Manuel Ugart and Diego Dalot’s goals took control of the first half-time command.
But they continued to throw away two goals while Coorent Tolisso and Nicolas Tagliafico scored to draw and took the game to an extra time.
Although Lyon Tolisso played in the last minute of normal time, Ryan Curk put the French club forward before the punishment of Alexander Lacazette appears to be sent through it, prompting some United fans to leave the move.
But then it became an incredible background because Bruno Fernandez’s penalty and the cool end of Kobe Main and their levels, before Old Trafford exploded when Harry Maguire grabbed his head in the winner and the seconds remained.
“The votes of the stadium were the best ever,” he added.
“Some people collect shirts and Iscarfs, but I want to keep that voice, the best voice in the world.
“I feel the people who have been forced to walk 4-2 because of traffic.
“We know we have little performance and we deserve all critics, but we have time to create something special this season.
Maguire agreed with his manager that the climate of Traford was something that helped his players one of the most memories.
“We have done a lot to go down to 10 men to 10 men in extra time,” he said.
“But we dig and showed our great soul, it’s what this stadium is doing.