Their goals against Brighton meant that Mbemo and Wesa scored for the 18th time in the same game during Brentford.
Only seven pairs of English Premier League history have a better general record.
“It’s an incredible achievement by the two players,” Frank said after the win against Brighton.
“When you have produced the main goalscorer in the past six seasons, it must be something we do well.
“I’m happy that Mbemo is shining and is now the main man for us. But I think that’s twins.
“Wissa is imaginary. In fact, he has scored more open goals against Brian. But Brothers are a penalty, incredible in penalties, assists, work ethics, an incredible player.
But they must seriously raise their goals if they want to record the record by Tottenham Hotspur Harry Kane and his son Hyung-min, both of whom have found the back of the network in 37 games for Spurs in the same game.